Clinical result of sintered bovine hydroxyapatite bone substitute: analysis of the interface reaction between tissue and bone substitute

NCUIR > college of Health Sciences and Technology > Institute of Biomedical Engineering > journal & Dissertation > Item 987654321/49866

Please use this identifier to cite or link to this item: http://ir.lib.ncu.edu.tw/handle/987654321/49866

Title:	Clinical result of sintered bovine hydroxyapatite bone substitute: analysis of the interface reaction between tissue and bone substitute
Authors:	Tsai,WC;Liao,CJ;Wu,CT;Liu,CY;Lin,SC;Young,TH;Wu,SS;Liu,HC
Contributors:	生物醫學工程研究所
Date:	2010
Issue Date:	2012-03-27 16:25:05 (UTC+8)
Publisher:	國立中央大學
Abstract:	Autogenic bone graft is the first choice for managing bone defects. However, donor site-associated morbidity and limited bone volume are constraints in clinical applications. Allografts can provide sufficient amounts for bone defects but have a high risk of infection. Bone substitute composed of hydroxyapatite (HA) is an alternative material for avoiding the aforementioned risks. Sintered bovine bone is a naturally occurring HA that has been proved to have excellent bioactivity for inducing osteoblastic expression and new bone formation in animal studies. The objective of this study was to evaluate the interactions between the tissue and the bone substitute composed of HA (sintered from bovine bone) in the human body. From 2003 to 2005, a total of 33 patients were enrolled to receive the sintered bovine HA as a bone substitute. Inclusion criteria were fractures with bony defects, benign bone tumors with a cavity, and spinal fusions. Bone healing was monitored by a series of radiographs, and bone microstructure was checked by scanning electron microscopy (SEM) and von Kossa staining. In 81.8% (27/33) of cases, significant fusion mass formation was visible in the radiographs after 6-12 months. New bone formation on the surface of the sintered bovine HA was seen under microscopic observation. Tight bonding between the interface of the bone and the sintered bovine HA was shown with SEM/energy-dispersive spectroscopy and von Kossa staining. Sintered bovine HA is a suitable material as a bone substitute to provide bone growth and promote bone healing.
Relation:	JOURNAL OF ORTHOPAEDIC SCIENCE
Appears in Collections:	[Institute of Biomedical Engineering] journal & Dissertation

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	768	View/Open

社群 sharing

Loading...